GENE ONLINE|News &
Opinion
Blog

2019-02-01| R&D

11-year-old becomes the first recipient of Novartis’s personalized CAR-T therapy

by Rajaneesh K. Gopinath
Share To

By Rajaneesh K Gopinath

The youngster from Watford was treated with the immunotherapy agent, Kymriah to counter a form of cancer that he has been battling for years.

Yuvan Thakkar became the first patient under the National Health Service (NHS) England, one of the four healthcare providers in the United Kingdom, to receive the Chimeric Antigen Receptor (CAR) T-cell therapy, Kymriah. He was diagnosed with Acute Lymphoblastic Leukemia (ALL) back in 2014 and has since undergone two rounds of chemotherapy and a bone marrow transplant. Usually in most cases (90%), such standard treatments substantially alleviate the disease but unfortunately his cancer relapsed. However, the timely arrival of personalized CAR-T cell therapy has given ample reasons for Yuvan and his family to be optimistic.

Kymriah – A brief history

In August 2017, the USFDA approved Novartis’s Kymriah (Tisagenleclecel) for the treatment of pediatric and young adult patients up to 25 years of age whose ALL relapsed after conventional treatments. The approval was based on the positive results from three key clinical trials and was the first FDA approved gene therapy. Last year it also received approval from the European Commission (EC). Kymriah was developed by Novartis in collaboration with University of Pennsylvania. The original cost of this personalized immunotherapy is £282,000 per patient, but all thanks to the deal between Novartis and NHS England last year, the price is now set at an affordable range.

CAR T-cell therapy

CAR T-cell therapy is a unique form of treatment wherein T-cells are obtained from the patient’s own blood and genetically modified to produce CAR T-cells. These modified T-cells are then infused in to the patient’s bloodstream where they destroy the tumor cells by specifically binding to cell surface proteins. Yuvan’s T-cells were extracted last November and were genetically modified at Rotterdam and Texas. Last week, Yuvan was infused with modified CAR-T cells at the Great Ormond Street Hospital in London thereby making him the first patient apart from the ones in clinical trials to undergo this ground-breaking therapy. Yuvan, a Lego enthusiast and an ardent cricket fan has plans to go see the Lego House in Denmark post his recovery. With that kind of mental toughness, he has become an inspiration for many.

References

  1. https://www.bbc.com/news/health-47058069
  2. https://www.gosh.nhs.uk/news/gosh-patient-first-receive-ground-breaking-new-cancer-therapy-nhs
  3. http://www.drugtopics.com/clinical-news/tisagenlecleucel-kymriah-acute-lymphoblastic-leukemia
  4. https://www.england.nhs.uk/2018/09/nhs-england-announces-groundbreaking-new-personalised-therapy-for-children-with-cancer/

 

©www.geneonline.com All rights reserved. Collaborate with us: service@geneonlineasia.com
Related Post
Novartis Shifts Gear To Phase 3 For Anti-Malaria Drug
2022-11-24
Hemgenix Marks Most Expensive Treatment Ever and First Gene Therapy for Hemophilia B
2022-11-22
Kyverna’s Lupus Nephritis Cell Therapy Received FDA Clearance, Aiming for Phase 1 Trial in 2023
2022-11-16
LATEST
Pfizer To Invest $1.26 Billion In Irish Plant, Forms New Vant Company Targeting Inflammation
2022-12-02
Scientists Identify New Genetic Variant Related to Obesity
2022-12-01
Micronbrane Medical Aspires to Further Clinical Collaboration Following the Successful Series A Funding
2022-12-01
FDA Revokes Authorization Of Eli Lilly’s COVID-19 Antibody
2022-12-01
Eisai Unveils Lecanemab Data Following Reports of Second Alzheimer’s Patient Death
2022-11-30
New CRISPR/Cas9 license agreement for ERS Genomics and Cosmo Bio
2022-11-30
Gland Pharma Dispels Rumors Of Fosun Sale, Acquires Cenexi In Separate Development
2022-11-30
EVENT
2022-12-10
64TH ASH ANNUAL MEETING & EXPOSITION
New Orleans, USA
2022-12-14
BIOHK2022
Hong Kong, China
2023-01-07
7th Asia Microbiome Conference
Taipei, Taiwan
Scroll to Top

Create an account with us now to say goodbye to all the pop-ups!