A protein link between brain diseases and leaky blood vessels

**Study Identifies Protein Deficiency in Brain Blood Vessels Linked to Neurological Disorders**

A recent study has identified reduced levels of a key protein as a common factor in several neurological disorders, including Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Researchers found that the deficiency primarily impacts the blood vessels within the brain, suggesting a potential connection between vascular health and these devastating conditions.

The findings highlight how diminished levels of this critical protein may contribute to “leaky” blood vessels in the brain. Such vascular dysfunction is increasingly recognized as playing a role in neurodegenerative diseases. The research underscores the importance of understanding how changes in blood vessel integrity could influence disease progression. Further investigation into this protein’s role may provide insights into shared mechanisms underlying these disorders.

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Source: https://medicalxpress.com/news/2025-04-protein-link-brain-diseases-leaky.html

Author

Mark Chiang