GENE ONLINE|News &
Opinion
Blog

2022-07-11| R&DTechnology

Alleviating Depression and Dementia with Transcorneal Electrical Stimulation

by Fujie Tham
Share To

A joint research team in Hong Kong discovered that stimulation of the eye surface can reduce depressive symptoms and improve cognitive functions in animals, leading to the possibilities of novel therapeutic applications for patients with chronic depression and neurological diseases such as Alzheimer’s

The scientists from LKS Faculty of Medicine, University of Hong Kong, and City University of Hong Kong published their findings in Brain Stimulation and Annals of the New York Academy of Sciences, as a result of the effort to develop alternative neuropsychiatric diseases treatments without the need of invasive deep brain stimulation.

Instead of implanting electrodes into the brain, the team achieved therapeutic effects by a non-invasive stimulation of the eye’s corneal surface (transcorneal electrical stimulation, TES), the technique resulted in antidepressant-like effects and reduced stress hormones in an animal model. Additionally, this technique induced gene expression involved in the development and growth of brain cells in the hippocampus, a region crucial for memory and learning.

Related article: BIO 2022: Challenges in Developing Cell and Gene Therapies

 

Electrical Stimulation of Eye May Cure Alzheimer’s 

 

Alongside encouraging hippocampal cells’ growth, the scientists observed that TES reduced beta-amyloid buildups, a characteristic of Alzheimer’s disease in a related study. Dr. Leanne Chan Lai-hang, co-author of this research shared: “Transcorneal electrical stimulation is a non-invasive method initially developed to treat eye diseases, and it would be a major scientific breakthrough if it could be applied to treat neuropsychiatric diseases.”

Treatment with TES effectively reduced blood stress hormone (corticosterone) levels in stressed test subjects, while upregulating neurogenesis-related markers. The team found that the expression of neurogenesis-related gene Ki67 is lower in stressed rats, subsequent treatment by TES restored expression to normal level.

“These research findings pave the way for new therapeutic opportunities to develop novel treatment for patients suffering from treatment-resistant depression and dementia. Nevertheless, clinical trials must be conducted to validate the efficacy and safety,” said Professor Chan Ying-shing.

 

©www.geneonline.com All rights reserved. Collaborate with us: service@geneonlineasia.com
Related Post
Eisai and Biogen’s Alzheimer’s Med, Leqembi, Granted FDA Approval
2023-01-09
R&D
Oral Diabetes Drug May Protect Elderly From Dementia
2022-12-16
Eisai Unveils Lecanemab Data Following Reports of Second Alzheimer’s Patient Death
2022-11-30
LATEST
NDA for Biogen-Sage’s Zuranolone Accepted by FDA, Marking Another Step Forward in Depression Drug Development
2023-02-07
BMS Returns $475 Million Cancer Asset To Dragonfly Therapeutics
2023-02-07
FDA Expands Approval For Takeda’s Takhzyro To Prevent Hereditary Angioedema Attacks
2023-02-06
Abbott’s New Technologies for Arrhythmia Treatment Secure FDA and European Approval
2023-02-04
First Human Trial for Marburg Virus Vaccine Reports Success
2023-02-03
Karuna Licenses Goldfinch’s Mood Disorder Candidates For Potential $535 Million
2023-02-03
Novel Bioengineered Wearable Edgeless Skin Brings Hope to Revolutionize Plastic and Reconstructive Surgery
2023-02-03
Scroll to Top

Create an account with us now to say goodbye to all the pop-ups!