April 26, 1932: British-Canadian Biochemist Michael Smith Was Born
Michael Smith (April 26, 1932 – October 4, 2000) was a British-born Canadian biochemist. Smith collaborated with Clyde A. Hutchison to develop a new technique called “site-specific mutagenesis”, and was able to determine the effect of a single mutant gene. In 1978, Michael Smith used polymerase chain reaction (PCR) to successfully induce mutations at specific locations on DNA with certain primers. Therefore, in 1993, Simth and Kary Mullis, who invented the PCR technology, were awarded the 1993 Nobel Prize in Chemistry.