Carbene Molecule Stabilized in Water, Validating 67-Year-Old Vitamin B1 Theory

Chemists have recently achieved the stabilization of a reactive carbene molecule in water, thereby confirming a 67-year-old theory concerning vitamin B1. The successful stabilization of the carbene, a feat once deemed unachievable, provides resolution to a long-standing biochemical puzzle. The research focused on a carbene, which is a carbon atom possessing only six valence electrons. Carbon atoms typically achieve stability with eight electrons; however, the electron deficiency in carbenes renders them chemically unstable and highly reactive. The recent work has demonstrated a method to stabilize this usually fleeting molecule in an aqueous environment. This new methodology may provide new processes that could be used in pharmaceutical development.

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Date: April 25, 2025

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Author

Mark Chiang

紐約 NYU Computer Science 碩士 紐澤西 UMDNJ Biomedical Informatics 博士 中研院博士後 台灣大學博士後