Co-use of Cannabis and Tobacco Linked to Increased Cognitive Impairment in Youth at Risk for Psychosis

A new study published in *Biological Psychiatry: Cognitive Neuroscience and Neuroimaging* indicates that adolescents and young adults at clinical high risk for psychosis experience greater cognitive impairment when they use both cannabis and tobacco compared to those who use neither substance. The research identifies a link between the co-use of these substances and diminished brain function, specifically within a demographic already identified as vulnerable to psychiatric conditions.

Researchers examined the neurocognitive performance of participants to determine how the combined use of cannabis and tobacco affects the brain. The study highlights that individuals who consume both substances demonstrate measurable differences in cognitive processing compared to non-users. By focusing on this specific population, the authors provide data on how substance use interacts with existing clinical risk factors for psychosis. The findings offer new insight into the neurological impact of these substances during the developmental stages of adolescence and early adulthood.

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Date: June 2, 2026

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GOAI