Dengue Virus NS2B3 Protein Clusters Induce Mitochondrial Fragmentation in Infected Cells

Researchers using single-molecule super-resolution microscopy have identified the formation of Dengue virus NS2B3 protein clusters on the mitochondrial network and observed their role in mitochondrial fragmentation. The study, published on June 27, 2026, details how these viral proteins localize to mitochondria and alter the organelle’s structural integrity during the infection process.

The investigation utilized advanced imaging techniques to track the spatial distribution of the NS2B3 protease complex within infected cells. The data show that these proteins aggregate into distinct clusters along the mitochondrial membrane. Following the formation of these clusters, the researchers observed a transition in the mitochondria from elongated networks to fragmented, punctate structures. This process suggests a direct link between the accumulation of viral NS2B3 proteins and the disruption of mitochondrial morphology, a common feature observed in cells affected by the Dengue virus.

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Source: GO-AI-ne1

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Date: June 27, 2026

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GOAI