DNA Nanoscaffolds Enable Stable Intracellular Recording From Multiple Neurons Simultaneously

A new method allows scientists to record the electrical activity of neurons inside living brains with greater precision than previously possible. Researchers developed a technique using self-assembling DNA nanostructures to create a scaffold for attaching electrodes directly to the cell membrane. This approach enables stable, long-term intracellular recordings from multiple neurons simultaneously.

The study, published in *Nature Nanotechnology*, details how researchers designed DNA tiles that self-assemble into a three-dimensional lattice. They then functionalized these DNA nanostructures with molecules that specifically bind to the neuronal cell membrane. After introducing these structures into brain tissue, the DNA scaffold effectively integrates with the cell membrane, creating a stable platform for attaching nanoelectrodes. The researchers demonstrated that these electrodes could record intracellular signals from neurons for extended periods, offering a significant improvement over existing methods that often suffer from instability or cell damage. Furthermore, the team showed that this technique could be used to record from multiple neurons at the same time, opening new avenues for studying neural circuits and brain function.

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Date: June 1, 2026

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GOAI