Exploring RNA Splicing as a Potential New Drug Avenue for Parkinson’s Disease
With the aging population of the world increasing, this age-dependent neurodegenerative disease is a substantial socioeconomic burden. Further complicating the situation is the lack of disease-modifying therapy, while the treatments available can only take care of the symptoms.
RNA mis-splicing as a potential mechanism of neurodegeneration.
The study by Boussaad et al. demonstrated that a mutation in one of the disease-causing gene, DJ-1 leads to mis-splicing of DJ-1.