GENE ONLINE|News &
Feng Zhang’s Team Engineer “Ultra-Compact” Cas-13 To Solve Packaging and Delivery Issues of RNA Editors
CRISPR-Cas13 is an RNA editing technique that can manipulate gene expression at the RNA level without modifying the genome. However, the delivery of RNA editors is perhaps the biggest barrier to the widespread adoption of this approach.
The therapeutic delivery of Cas13-based RNA editing systems remains challenging, in part because the size of Cas13-based RNA editors developed so far exceeds the packaging capacity of adeno-associated virus (AAV), the most widely used viral vector for gene delivery.
The therapeutic delivery of Cas13-based RNA editing systems remains challenging, in part because the size of Cas13-based RNA editors developed so far exceeds the packaging capacity of adeno-associated virus (AAV), the most widely used viral vector for gene delivery.
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