Genetic Evolution of Keratinocytes Linked to Development of Cutaneous Squamous Cell Carcinoma

Recent research has identified the genetic evolution of keratinocytes as a key factor in the development of cutaneous squamous cell carcinoma (cSCC), a common and aggressive form of skin cancer. The study, conducted by Tandukar, Deivendran, Chen, and their team, provides detailed insights into the molecular changes that occur as keratinocytes progress from normal cells to malignant ones. The findings were published in *Nature Communications*.

The research outlines a comprehensive timeline of genetic alterations in keratinocytes during their transformation into cSCC. By analyzing these changes at the molecular level, the study highlights specific mutations and pathways involved in this progression. This work contributes to understanding how normal skin cells evolve into cancerous forms and may inform future approaches to prevention or treatment.

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Date: November 27, 2025

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