Lactobacillus acidophilus TMPC 41127 Reduces Salmonella Typhi Biofilm Formation and Downregulates Virulence Genes

A recent study investigated the ability of *Lactobacillus acidophilus* TMPC 41127, a probiotic strain isolated from traditional cheese, to inhibit *Salmonella Typhi* biofilms and virulence genes. Researchers examined the probiotic’s impact on biofilm formation, a key factor in *Salmonella Typhi* persistence and antibiotic resistance, and its influence on the expression of genes responsible for the bacteria’s virulence.

The study found that *Lactobacillus acidophilus* TMPC 41127 effectively reduced *Salmonella Typhi* biofilm formation. Further analysis revealed that the probiotic strain also downregulated the expression of several virulence genes in *Salmonella Typhi*. These genes play a crucial role in the bacteria’s ability to infect and cause disease. The findings suggest that *Lactobacillus acidophilus* TMPC 41127 holds potential as a probiotic agent to combat *Salmonella Typhi* infections by interfering with biofilm development and reducing the expression of virulence factors.

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Source: GO-AI-ne1

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Date: May 3, 2026

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GOAI