Lacy La Fever Presentation Highlights Impact of Calvert and Chatelut Formulas on Carboplatin Dosing Outcomes

Lacy La Fever, PharmD, MS, presented information regarding outcomes linked to various carboplatin Area Under the Curve (AUC) dosing strategies. The presentation focused on different methods of calculating and administering carboplatin dosages based on a patient’s kidney function and desired drug exposure. During the presentation, La Fever discussed how differing AUC targets and calculation methods can affect treatment efficacy and toxicity profiles. The information presented highlighted the importance of considering individual patient factors when determining the optimal carboplatin dosing strategy. The presentation noted that clinicians utilize different formulas to calculate carboplatin dosages based on a patient’s glomerular filtration rate (GFR). Some common formulas that were mentioned were the Calvert formula and the Chatelut formula. La Fever indicated that the choice of formula and target AUC value can influence both the effectiveness of the chemotherapy and the risk of side effects such as myelosuppression.

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Date: May 9, 2025

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Author

Mark Chiang

紐約 NYU Computer Science 碩士 紐澤西 UMDNJ Biomedical Informatics 博士 中研院博士後 台灣大學博士後