2021-10-28| In-depthSpecial

New Age Gene Editors Take Us Closer to CRISPR-Based Gene Therapy

by Sahana Shankar
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Genome editors are like word processor spell-checks which correct the genetic code in case of misspelling or errors, enabling the reversal of disease-causing mutations. However, not all editors are equally efficient at detecting and correcting DNA errors.

An added layer of complication is that some editors work well in certain cell types and not others; some editors may add undesired mutations and some may not reach the target gene as required. This has spurred a new era of gene editing research focused on improving the technology to be able to cure genetic diseases. 

In a series of studies published recently, scientists from MIT’s Broad Institute and Princeton University report a set of improved molecular tools to bring gene editors closer to therapeutic applications.

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