GENE ONLINE|News &
November 8, 2012: Completion of the Liver Cancer Genome
Victor Ambros discovered that the lin-4 gene produces a microRNA that negatively regulates the lin-14 gene, while Gary Ruvkun cloned the lin-14 gene and together they found that the lin-4 microRNA binds to a matching sequence in lin-14's mRNA to inhibit its function.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. The whole genome sequence of HCC was completed by RIKEN, a Japanese research institution, and was published on November 8, 2012. The result revealed many new cancer-associated genes, a variety of genomic alterations, and the common integration sites for hepatitis B virus (HBV) genome. The report was a step forward for studying the HBV virus and for developing new drugs for liver cancer.
Reference
https://www.ncbi.nlm.nih.gov/pubmed/23142287
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