OXCT1 Identified as Key Metabolic Regulator in Suppressing Colorectal Cancer Liver Metastasis

Researchers have identified 3-oxoacid CoA-transferase 1 (OXCT1) as a significant factor in suppressing liver metastasis in colorectal cancer, according to findings published in the journal *Genes & Diseases*. The study, conducted by scientists from Chongqing Medical University and affiliated hospitals, highlights OXCT1’s role as a metabolic regulator within a newly discovered signaling pathway. This research sheds light on the interplay between metabolism, epigenetics, and oncogenic processes in colorectal cancer liver metastasis (CRLM).

The study reveals that OXCT1 operates within a metabolic-epigenetic-oncogenic signaling axis that had not been previously recognized. Researchers suggest this pathway plays a critical role in controlling the progression of CRLM. The findings provide insight into potential therapeutic targets for managing liver metastases in colorectal cancer patients.

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Date: February 3, 2026

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GOAI