Researchers Develop Fluorescent Biosensor to Study Immune Response to DNA

A team of researchers has bioengineered a fluorescent biosensor designed to study the immune system’s response to aberrant DNA. The work, led by Ikerbasque Research Professor Sergio P. Acebrón from the University of the Basque Country and Heidelberg University, focuses on cGAS, a cellular DNA detector that plays a critical role in signaling the immune system during viral and bacterial infections, cell death, and cancer-related transformations.

The cGAS protein is part of a conserved cellular process that alerts the immune system when foreign or damaged DNA is detected within cells. By engineering this mechanism into a fluorescent biosensor, researchers aim to provide new tools for observing how the immune system reacts under various conditions. This development could enhance understanding of immune responses in scenarios such as infection or cancer progression.

Date: March, 2025

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Author

Mark Chiang

紐約 NYU Computer Science 碩士 紐澤西 UMDNJ Biomedical Informatics 博士 中研院博士後 台灣大學博士後