Researchers Identify CD43 as an Immune Evasion Mechanism in Acute Myeloid Leukemia

Researchers have identified a previously unknown immune evasion mechanism in acute myeloid leukemia (AML), involving the glycoprotein CD43. The study, conducted by scientists from Mass General Brigham, Dana-Farber Cancer Institute, and the Broad Institute of MIT and Harvard, highlights CD43 as a “don’t eat me” signal that helps cancer cells avoid destruction by the immune system. The findings were published in the journal *Science*.

The research reveals that CD43 plays a critical role in enabling AML cells to evade macrophages, which are immune cells responsible for engulfing and destroying harmful entities in the body. By acting as an inhibitory signal, CD43 prevents macrophages from attacking AML cells. This discovery challenges existing paradigms in cancer immunotherapy and opens new avenues for understanding how certain cancers resist immune responses. The identification of this novel mechanism could potentially inform future therapeutic strategies aimed at targeting CD43 to enhance immune system activity against AML.

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Date: April 10, 2026

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GOAI