Researchers Identify Skin Neutrophils That Generate Protective Extracellular Matrix

A study conducted by scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has identified a unique subset of immune cells in the skin that contribute to its structural defense. The research, led by Dr. Andrés Hidalgo, revealed that certain neutrophils produce extracellular matrix components, which play a role in preserving the skin’s integrity and resistance.

Neutrophils are typically known for their role in combating infections, but this discovery highlights an additional function specific to the skin. According to the findings, these specialized neutrophils generate extracellular matrix material that acts as a protective “shield,” reinforcing the skin’s physical barrier against external stressors. This population of neutrophils appears to be distinct from those found elsewhere in the body and is tailored to support skin health and resilience.

Date: March, 2025

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Mark Chiang