Researchers Identify SLK as a c-Myc Co-regulator Using Light-Triggered Proximity Labeling

Researchers have identified a molecular interaction between the protein c-Myc and the protein SLK that occurs specifically within cancer cells. A study published in *Nature Chemical Biology* details how a team led by Milione, Tong, and Wolfe utilized a light-triggered proximity-labeling technique to map the proteins located in the immediate vicinity of c-Myc in living cells.

The research team developed this labeling strategy to observe protein behavior in real-time within a cellular environment. By triggering the proximity-labeling process with light, the scientists identified SLK as a co-regulator that associates with c-Myc. This finding provides new data regarding the molecular partnerships that influence c-Myc activity, a protein frequently linked to tumor development and progression. The study outlines the methodology used to isolate these interactions and highlights the role of SLK in the context of c-Myc-driven cancer biology.

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Date: August 13, 2026

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GOAI