Shanghai Researchers Identify PGG’s Role in Targeting Methionine Metabolism to Induce Pyroptosis in Cancer Cells

Researchers at Shanghai Medical College, Fudan University, have identified a new mechanism that could significantly impact cancer immunotherapy. The study, led by Professor Qun-Ying Lei, focuses on the natural compound PGG and its ability to target methionine metabolism. This dual-action approach triggers pyroptosis—an inflammatory form of programmed cell death—and enhances the body’s anti-tumor immune response. The findings highlight the critical role of the enzyme methionine adenosyltransferase 2A (MAT2A) in regulating this process.

The research sheds light on how PGG influences methionine metabolism to induce pyroptosis in tumor cells. Pyroptosis is known for releasing cellular contents that activate immune cells, potentially boosting the immune system’s ability to attack tumors. By targeting MAT2A, a key enzyme involved in methionine metabolism, PGG appears to disrupt cancer cell survival while simultaneously stimulating an immune response. These findings provide new insights into how metabolic pathways can be leveraged to enhance cancer treatments and improve patient outcomes.

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Date: April 8, 2026

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GOAI