Single DNA mutation disrupts key tumor-suppressing pathways, elevating blood cancer risk

**Single DNA Mutation Linked to Disruption of Tumor-Suppressing Pathways in Blood Cancer**

Australian researchers have identified a single mutation in the DNA sequence of a methylation enzyme that disrupts critical tumor-suppressing pathways, potentially increasing the risk of blood cancers. The findings shed light on how genetic alterations can interfere with cellular mechanisms designed to prevent cancer development.

The study focused on the role of methylation enzymes, which are responsible for regulating gene expression through chemical modifications. Researchers found that a specific mutation in the DNA coding for one such enzyme leads to dysregulation of pathways essential for suppressing tumor formation. This disruption may contribute to the onset and progression of blood cancers. The discovery highlights an area for further investigation into targeted treatments aimed at restoring proper function within these pathways.

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Source: https://medicalxpress.com/news/2025-04-dna-mutation-disrupts-key-tumor.html

Author

Mark Chiang