GENE ONLINE|News &
Opinion
Blog

2021-11-22| Special

Study Advocates Cautious Application of CRISPR in Designing Therapeutics

by Arvind C. Shekhar
Share To
CRISPR is a powerful technology that has enabled easy disruption of desired genes and has revolutionized the field of genome editing. CRISPR-based editing has been considered for various applications in medicine, but it also has its shortcomings such as off-target effects, generation of unexpected chromosomal alterations, or potential immunogenicity.

Studies have demonstrated that DSBs induced during CRISPR-based gene knockout can lead to a DNA damage response mediated by p53, a tumor-suppressor gene that initiates programmed cell death before the cells can become cancerous. Presently it is unclear whether p53 selection can happen broadly across multiple different cell types, and whether stronger p53 selection happens when certain genes or parts of the genome are targeted.

A recent study published in Nature Communications shows that CRISPR-Cas9 based gene-editing can confer a selective advantage to cells harboring mutations in genes associated with cancer irrespective of their cell types.

GO Prime with only $1.49 now

LATEST
Axsome’s AXS-05 Achieves Endpoints In Alzheimer’s Agitation Trial
2022-11-29
Spectrum to Cut 75% of Staff and NSCLC Program Following CLR
2022-11-28
Full-Life Technologies to Acquire Focus-X Therapeutics, Bolstering Peptide-Focused Radiopharmaceutical Pipeline
2022-11-28
Medeologix Acquires Three Silicon Valley Medical Device CDMO Companies and Establishes One-Stop Shop Mass Production Facilities in Taiwan
2022-11-28
GenFleet Therapeutics to Present Data from Phase I Trial of GFH009 Monotherapy at the 2022 Annual Meeting of American Society of Hematology (ASH)
2022-11-28
Everest’s Renal Drug Gets Placed On Fast Track For Approval In Taiwan And Korea
2022-11-28
Canada Authorizes Roche’s Polivy as First-Line Lymphoma Treatment
2022-11-27
EVENT
2022-12-01
BIOCHINA 2022
Online
2022-12-10
64TH ASH ANNUAL MEETING & EXPOSITION
New Orleans, USA
2022-12-14
BIOHK2022
Hong Kong, China
2023-01-07
7th Asia Microbiome Conference
Taipei, Taiwan
Scroll to Top

Create an account with us now to say goodbye to all the pop-ups!