Study at University of Pittsburgh Explores Why Some with Down Syndrome Avoid Dementia

A groundbreaking study conducted by the University of Pittsburgh’s Swanson School of Engineering is shedding light on why some individuals with Down syndrome (DS) maintain cognitive stability despite a high risk of developing Alzheimer’s disease (AD)-related dementia. This research could potentially benefit not only those within the DS community but also enhance broader understanding of Alzheimer’s disease.

Individuals with Down syndrome face a lifetime risk exceeding 90% for developing dementia as they age, primarily due to Alzheimer’s disease. However, there remains a subset of the DS population that does not follow this expected pattern. The University of Pittsburgh’s new study aims to uncover the factors contributing to this unexpected cognitive stability in certain individuals with DS.

The findings from this research may provide critical insights into both the progression and possible prevention strategies for Alzheimer’s disease among the general population as well as those with Down syndrome. By identifying why some individuals with DS do not develop dementia, researchers hope to apply these insights towards broader therapeutic approaches for Alzheimer’s disease.

Date: March 1, 2025

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Author

Mark Chiang

Ph.D in Biomedical Informatics Head of AI at GeneOnline