Study Finds Sex-Based Differences in Spatial Cognition Responses to 10 Hz and 40 Hz tACS in Mice

A recent study conducted by researchers Zhang, Ren, and Chen has revealed notable differences in how transcranial alternating current stimulation (tACS) affects spatial cognition in mice, with findings indicating variations based on sex. The research focused on two specific frequencies of tACS—10 Hz and 40 Hz—both commonly studied in neuroscience for their potential effects on brain function.

The study examined the impact of these frequencies on male and female mice to determine whether sex plays a role in cognitive responses to tACS. Researchers observed distinct differences between the sexes in how spatial cognition was influenced by the stimulation. The investigation highlights the importance of considering biological variables such as sex when studying neural modulation techniques like tACS. Further details about the methodology and results were not disclosed in this report but are available through related scientific publications.

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Date: November 28, 2025

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