Study Identifies Epstein-Barr Virus Antibodies Linked to Multiple Sclerosis Development

A recent study has uncovered a connection between antibodies produced in response to the Epstein-Barr virus (EBV) and the onset of multiple sclerosis (MS). Researchers found that these antibodies, which are typically generated to combat EBV, mistakenly target a brain protein known as GlialCAM. This misdirected immune response is believed to trigger autoimmune activity associated with MS.

The findings suggest that the interaction between EBV antibodies and GlialCAM may play a role in initiating the neurological damage characteristic of MS. GlialCAM is involved in maintaining normal brain function, and its disruption by these antibodies could contribute to the disease’s progression. The research provides insight into how viral infections might influence autoimmune disorders like MS, though further investigation is needed to fully understand this relationship.

Date: 12 March, 2025

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Author

Mark Chiang

Ph.D in Biomedical Informatics Head of AI at GeneOnline