Study Identifies Role of C-reactive Protein in Diabetic Kidney Inflammation

A research team from the School of Chinese Medicine at the University of Hong Kong’s LKS Faculty of Medicine has identified a mechanism by which C-reactive protein (CRP) contributes to kidney inflammation in diabetic patients. The study found that CRP exacerbates diabetic kidney disease (DKD) through a pathway involving the Smad3-NLRP3 inflammasome. This discovery highlights potential targets for future therapeutic approaches to address DKD.

The findings suggest that CRP, a protein commonly associated with inflammation, plays a direct role in worsening kidney damage linked to diabetes. Researchers determined that the Smad3-NLRP3 inflammasome-dependent mechanism is central to this process, providing insight into how inflammation progresses in diabetic kidneys. The study proposes that further exploration into therapies targeting either CRP or the Smad3-NLRP3 pathway could pave the way for new treatments aimed at mitigating DKD-related complications.

Date: 13 March, 2025

Newsflash | Powered by GeneOnline AI

Related posts:

Study Reveals Distinct Immune Signatures in Myocarditis Linked to COVID-19 and Vaccines Alarm Raised Over Ultra-Processed Foods Dominating Baby and Toddler Market Tests on Sunglasses Show Deficiencies in Protection Against Ultraviolet Rays PepGen’s New Drug Candidate Shows Promising Results in Treating Rare Muscle Disorder

Author

Mark Chiang

Ph.D in Biomedical Informatics Head of AI at GeneOnline