Study Uncovers Separate Neural Circuits for Pain and Itch in the Brain

A groundbreaking study has revealed that the human brain processes pain and itch through distinct neural circuits located in the anterior cingulate cortex (ACC). Researchers identified two specific types of neurons responsible for differentiating these sensations, shedding new light on how the brain interprets discomfort.

The study found that one group of neurons responds to both pain and itch stimuli, while another set is selectively activated by either pain or itch. This discovery highlights a sophisticated mechanism within the ACC that enables the brain to distinguish between these two sensations, which are often closely linked yet fundamentally different.

The findings could pave the way for more targeted treatments for chronic pain and itch conditions by focusing on these specialized neural pathways. The research underscores the complexity of sensory processing in the brain and opens new avenues for understanding how humans experience physical discomfort.

Date: March 5, 2025

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Author

Mark Chiang

Ph.D in Biomedical Informatics Head of AI at GeneOnline