UCLA Researchers Develop SEE-CITE Technology to Precisely Map Small Molecule Binding Sites on Proteins
Researchers at UCLA have introduced a new technology called SEE-CITE, which significantly improves the ability to identify where small molecules bind to proteins. This advancement builds on an existing method known as photo-crosslinking and allows scientists to map these binding sites with greater precision and reliability. The development has potential implications for accelerating drug discovery and advancing molecular biology research.
The SEE-CITE technology refines the process of photo-crosslinking by enhancing its accuracy in pinpointing interactions between small molecules and proteins. This capability is critical for understanding how drugs interact with their targets at a molecular level, which can inform the design of more effective therapies. Researchers describe this approach as a step forward in addressing challenges associated with studying complex biological systems.
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Date: April 28, 2026
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