GENE ONLINE|News &
Opinion
Blog

2021-08-05| China

Zai Lab, Schrödinger Collaborate to Advance Cancer Program

by Kathy Huang
Share To

The process of drug discovery has been lengthy and costly, and many pharma companies are introducing computational tools to accelerate the process. The powerful solution has caught the attention of China’s pharma giant Zai Lab.

On August 4th, Zai Lab announced a collaboration with the New York-based software company Schrödinger to work on an oncology program targeting the DNA damage repair pathway. According to the deal, Zai Lab will pay an undisclosed upfront payment to Schrödinger, plus milestone payments up to $338 million.

 

Adding Computational Platform to Zai’s Oncology Pipelines

Equipped with the physics-based computational platform, Schrödinger enables rapid and high-quality drug discovery through integrating predictive modeling and data analysis.

Zai Lab will add Schrödinger’s platform to advance its eighteen ongoing oncology pipeline projects, including ovarian and gastric cancer treatment Niraparib (PARP). PARP is a family of proteins playing a key role in the DNA repair pathway, and PARP inhibitors are effective in treating tumors with defects in DNA repair.

 “This program will complement our existing discovery efforts in the DNA damage response pathway in addition to potential combinatorial approaches within our pipeline, such as with the PARP inhibitor Zejula,” said Alan Sandler, M.D., President and Head of Global Development, Oncology, Zai Lab.

 

Zai Lab’s Recent Oncology Business Deals

In June, Zai Lab signed a licensing deal with Mirati Therapeutics to develop adagrasib, a small molecule KRAS inhibitor in China.

In the same month, it inked a deal with MacroGenics to develop preclinical bispecific antibodies in oncology. Zai Lab paid MacroGenics $25 million upfront payments and up to $1.4 billion biobucks for the programs. This was the second collaboration between two companies since 2018.

©www.geneonline.com All rights reserved. Collaborate with us: service@geneonlineasia.com
Related Post
R&D
Senescent Cancer Cells Vaccine Boost Immune Response
2022-11-07
AstraZeneca’s Liver Cancer Treatment Combination Snatches FDA Approval
2022-10-24
FDA Drops New Oncology Development Guidelines
2022-10-18
LATEST
Repairing Genetic Mutations in Neurological Diseases with RNA Targeting Strategy
2022-11-25
AstraZeneca Thailand Wins Two ACES Awards 2022: “Industry Champions of the Year” and “Community Initiative”
2022-11-24
Mabwell Announces the U.S. FDA approval of 9MW3011 (FIC) for IND
2022-11-24
Novartis Shifts Gear To Phase 3 For Anti-Malaria Drug
2022-11-24
Moving Past Animal Models with Better Data for Drug Discovery
2022-11-23
IonOpticks ushers in a new age of proteomics with Aurora Frontier
2022-11-23
Korea Ginseng Corp.: As an adaptogenic herb, Korean red ginseng boosts the human immune response
2022-11-23
EVENT
2022-12-01
BIOCHINA 2022
Online
2022-12-10
64TH ASH ANNUAL MEETING & EXPOSITION
New Orleans, USA
2022-12-14
BIOHK2022
Hong Kong, China
2023-01-07
7th Asia Microbiome Conference
Taipei, Taiwan
Scroll to Top

Create an account with us now to say goodbye to all the pop-ups!