6 March, 2014: First time Scientist gene-editing Immune Cells Successful, open a new treatment possibility for AIDS
A research team from the Perelman School of Medicine, University of Pennsylvania, enrolled 12 patients in an uncontrolled study of a single dose of ZFN-modified autologous CD4 T cells. The patients had the chronic aviremic HIV infection while they were receiving highly active antiretroviral therapy. After the infusion of 10 billion autologous CD4 T cells, the blood level of HIV DNA decreased in most patients. This study was a milestone for gene-editing technology application on fatal disease treatment.