However, not all patients respond well to immunotherapy, suggesting other immune evasion pathways in cancers. Researchers from MIT and Brigham and Women’s Hospital employed nanotechnology to unravel a novel mechanism of cancer cells to attack and suppress immune cells.
Co-culture of breast cancer cells with effector T cells and subsequent high-resolution imaging showed a physical linkage between cancer cells and nearby T cells with an average width of 100-1000nm. These nanotubes were composed of actin and other cytoskeletal proteins, suggesting that they may be involved in intercellular transport.
In a breakthrough study published recently in Science, researchers from the University of Colorado Anschutz Medical campus have revealed how viral RNAs use a combination of static and dynamic RNA structures to bind host machinery through highly noncanonical interactions.
Using cryogenic electron microscopy (cryo-EM), the investigators have visualized the structure of the mysterious viral transfer RNA (tRNA)-like structure (TLS) from the brome mosaic virus (BMV), which affects essential viral processes, including viral replication, translation, and genome encapsidation.