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2024-03-06|

Antengene to Present Four Preclinical Abstracts at AACR 2024, Highlighting Focus on Cancer Immunology, Targeted Agents and Novel Technology Platforms

by GeneOnline
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  • The first preclinical abstract on ATG-O42 (MTAPnull-selective small molecule PRMT5 inhibitor) as well as the latest data on the proprietary T cell engager platform, AnTenGagerTM, and ATG-102 (LILRB4 x CD3 T cell engager).
  • The first view of ATG-022 (Claudin 18.2 ADC) companion diagnostic.

SHANGHAI and HONG KONG, March 6, 2024 /PRNewswire/ — Antengene Corporation Limited (AntengeneSEHK: 6996.HK), a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for cancer, today announced that four preclinical abstracts have been selected as poster presentations at the 2024 American Association for Cancer Research Annual Meeting (AACR 2024), taking place from April 5th to April 10th at the San Diego Convention Center in San Diego, California, the United States.

“The promising data we are about to present at this year’s AACR Annual Meeting underscore Antengene’s ongoing focus on the innovation of oncology drugs, our strong in-house expertise in developing antibody and small molecule therapies and impressive platform innovations,” said Dr. Bing Hou, Antengene’s Head of Discovery Science & Translational Medicine. “Tumor selective epigenetic inhibitors is one of the areas of focus for Antengene. At the meeting, we will present the first data from our MTAPnull-selective PRMT5 inhibitor program and the first candidate from our companion diagnostic program, a CDx to support our novel Claudin 18.2 ADC, ATG-022. In addition, we are keenly interested in T cell engagers and look forward to presenting results on Antengene’s unique AnTenGager™ platform and one of our first lead programs targeting LILRB4 for Acute Myelogenous Leukemia (AML). Building on those promising results, we will forge ahead with our innovative work for the benefit of more cancer patients around the world.”

Details of the posters:

ATG-042 (MTAPnull-selective PRMT5 Inhibitor)
Title: Preclinical characterization of ATG-042, a novel MTAPnull-selective PRMT5 inhibitor
Abstract: 4592
Session Category: Experimental and Molecular Therapeutics
Session Title: HDAC and Methyltransferase Inhibitors
Date: April 9, 2024
Time: 9:00 AM – 12:30 PM (Pacific Time)
           12:00 AM – 3:30 AM, April 10, 2024 (Beijing Time)
Location: Poster Section 24

Companion Diagnostic Antibody for ATG-022 (Claudin 18.2 ADC)
Title: Development of a novel companion diagnostic immunohistochemistry antibody for Claudin 18.2-targeted therapies
Abstract: 1032
Session Category: Clinical Research
Session Title: Diagnostic Biomarkers 1
Date: April 7, 2024
Time: 1:30 PM – 5:00 PM (Pacific Time)
           4:30 AM – 8:00 AM, April 8, 2024 (Beijing Time)
Location: Poster Section 42

AnTenGagerTM Platform
Title: AnTenGagerTM, a novel “2+1” T cell engager platform, enables conditional T cell activation with reduced risk of CRS
Abstract: 6343
Session Category: Clinical Research
Session Title: Antibodies 2
Date: April 9, 2024
Time: 1:30 PM – 5:00 PM (Pacific Time)
           4:30 AM – 8:00 AM, April 10, 2024 (Beijing Time)
Location: Poster Section 41

ATG-102 (LILRB4 x CD3 T Cell Engager)
Title: ATG-102, a novel LILRB4 x CD3 T cell engager, targeting two non-overlapping epitopes of LILRB4, for the treatment of monocytic AML
Abstract: 2372
Session Category: Clinical Research
Session Title: Antibodies 1
Date: April 8, 2024
Time: 9:00 AM – 12:30 PM (Pacific Time)
           12:00 AM – 3:30 AM, April 9, 2024 (Beijing Time)
Location: Poster Section 38

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