The discovery of iPSCs has been considered as a landmark in medical research which can drive innovation in therapies. While the scientific basis of pluripotency is elegant and can have a huge impact when we can generate an endless supply of required cell types with therapeutic potential, the practical application of developing iPSCs is very challenging.  At the 63rd Annual Meeting of the American Society of Hematology, scientists working on stem cell therapies reviewed the latest innovation, challenges and future directions of stem cell-derived immunotherapies.