“Metabolomics shares more resemblance with pathophysiology than with genomics and proteomics. It maps the interaction between small molecules and is the blueprint of metabolites formation!" Ming-Shi Shiao, Professor at the Department of Biomedical Sciences, Chang Gung University stated excitingly. Practically radiating with enthusiasm, Professor Shiao shared his journey of venturing from chemistry professional to metabolomics, and how metabolomics plays a critical rolein the precision medicine era. He also put forward his expectations and suggestions for Taiwan’s future in this field.