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2024-04-16| In-DepthR&DTrending

Sequencing Revolution Spotlights the Titans of NGS Innovation

by Bernice Lottering
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NGS Pioneers: Instrument Companies to Keep an Eye on

The past three years have seen dynamic shifts within the next-generation sequencing (NGS) sector. Numerous competitors have introduced novel sequencing technologies, challenging the established market leader, Illumina. This period followed an eventful 2023 for Illumina, marked by significant changes in its executive leadership, operational strategies, and board composition. Now, in Q2 of 2024, the industry will gauge whether sequencing customers are willing to transition from Illumina to its competitors. Notable rivals, such as PacBio, Singular Genomics, and Element Biosciences, have introduced compelling alternatives to Illumina’s offerings.

Illumina Dominates the Field

The global NGS market is predicted to reach around US$ 34.19 Billion by 2030. NGS has revolutionized genomics, allowing for rapid and high-throughput DNA sequencing. This technology enables simultaneous sequencing of multiple DNA fragments, transforming research in genomics, personalized medicine, and various fields including biology, medicine, and agriculture. Techniques such as Illumina sequencing, introduced in the mid-2000s, have significantly reduced the time and cost of genetic studies, personalized medicine, and diagnostics. The scalability and precision of NGS have redefined biology, driving breakthroughs in genetic information, evolution, and disease mechanisms.

Former Illumina senior vice president, now executive chair of Ryght.AI, Alex Dickinson, expressed concerns about the sustainability of newer companies in the NGS industry due to their high burn rates and limited funding availability. Meanwhile, Illumina remains focused on advancing its NovaSeq X sequencing system, which received 390 orders and shipped 352 units in 2023, marking it as their most successful high-throughput product launch to date, as stated by CEO Jacob Thaysen during the company’s Q4 2023 earnings call earlier this year. 

However, irrespective of the performance of Illumina and its competitors in the current year, a report by Research and Markets highlights that the commercial potential of NGS has barely been tapped. The findings forecast a significant expansion in the NGS market, projecting it to more than triple over the next seven years. Specifically, from $10.63 billion in the present year to $34.19 billion by 2030, with a compounded annual growth rate of 18.16%.

NGS Industry: Instrument Companies to Keep an Eye on

The global NGS market is expanding due to its growing adoption in scientific prognosis. NGS’s comprehensive genetic data has enhanced diagnosis and personalized treatment decisions. Increasing demand for precision medicines and advancements in genomic research broaden NGS applications, fostering market growth. Its indispensable role in medical workflows contributes significantly to the market’s continuous expansion.

Here we can see a concise representation of the information focusing on sequencing instrument providers and workflow solution providers in the genomics industry. The data shows one table comprising eight companies offering NGS instruments and another consisting of three companies providing Sanger instruments. Including Thermo Fisher Scientific in both tables, there are a total of 10 sequencing instrument providers. Additionally, workflow solution providers Agilent Technologies, QIAGEN, and Roche are highlighted separately for their contributions to the sequencing industry.

Providers of NGS Instrumentation
Providers of NGS Instrumentation. These companies are listed alphabetically and not ranked based on revenue or other metrics.
Providers of Sanger Sequencing Instrumentation
Providers of Sanger Sequencing Instrumentation. These companies are listed alphabetically and not ranked based on revenue or other metrics.
Providers of Workflow Solutions
Providers of Workflow Solutions. These companies are listed alphabetically and not ranked based on revenue or other metrics.

Genomic Frontiers, NGS Innovations & Growth Opportunities Ahead

The genomics industry is rapidly advancing, fueled by innovations in NGS instrumentation and workflow solutions. Key players in NGS instrumentation are driving advancements in whole genome and long-read sequencing technologies. Additionally, companies are innovating Sanger sequencing instrumentation for applications like genome edits confirmation. Workflow solution providers play a vital role in ensuring efficient NGS workflows. With the increasing adoption of NGS across various sectors, including healthcare and research, the future of genomics promises significant opportunities for precision medicine and scientific discovery.

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