GENE ONLINE|News &
Opinion
Blog

.

Зеркало официального сайта всегда доступно для входа на Мостбет, даже при ограничениях. Скачать Mostbet – это шаг к удобству и азартным развлечениям.

Если вы ищете место для увлекательных ставок, обратите внимание на Joycasino, где лучшие предложения для игроков ждут вас.
last added cars
2023-07-31| R&D

Revolutionizing Anticancer Therapy with Click Chemistry

by GeneOnline
Share To

Researchers at UCL and Stanford University have developed an anti-cancer therapy using “click chemistry”. They were able to create a three component therapy that targets cancer cells. This new approach of using click chemistry for developing cancer immunotherapies opens up new possibilities for future therapeutic advancements. 

Related Article: Three Scientists Jointly Win Nobel Prize for Innovations in Click Chemistry

Advancing Cancer Therapies 

In a study published in Nature Chemistry, scientists used bispecific T cell engagers (BiTEs) to promote the death of cancer cells by bringing the cells close to cytotoxic T cells. Cytotoxic T cells are a type of immune cells that are able to kill foreign cells. They generated three-protein conjugates using click chemistry, a chemical method, and tested their efficacy in vitro. The generated conjugates consist of three components, the first targets cancer cells, and another recruits T cells. Finally, the last component knocks out the cancer cell’s defenses. 

The component that knocks out the cell’s defenses consists of a checkpoint inhibitor, PD-1 blocking antibody, or sialidase enzyme. A PD-1 blocking antibody is used to treat advanced forms of lung and skin cancer. On the other hand, sialidase is an enzyme that strips sialic acids (sugars) from cancer cells’ surfaces. These sugars are generally present in greater amounts in cancer cells than in normal cells, but more importantly, they help cancer cells by switching off approaching immune cells. The therapy they developed that used sialidase was shown to be especially effective at killing breast cancer cells grown in vitro. 

What is Click Chemistry? 

The Nobel Prize in Chemistry for 2022 was awarded to K. Barry Sharpless, Carolyn R. Bertozzi, and Morten Meldal for the development of click chemistry and bioorthogonal chemistry. In click chemistry, chemicals are clicked together to form new molecules, like Lego blocks being put together. These building blocks are able to be joined, or “clicked” together to form desired molecules because they have two click handles that are able to attach to each other without the production of toxic by-products. This allows for the easy creation of molecules with new properties that would otherwise require extensive skills and equipment.  

Click chemistry is a chemical way of generating bispecific antibodies, as opposed to the typically used expression-based methods like protein engineering. Click chemistry has higher reactant specificity and tolerance to functional groups. Additionally, it offers greater modularity, speed, and reproducibility. Dr. Peter Szij, from the Chemistry Department at University College London, said, “Click chemistry is a quicker and more adaptable way to build these multifunctional anti-cancer agents than protein engineering. It’s relatively easy to attach click ‘handles’ to proteins, so you can try lots of combinations quickly to test what might work best. Using protein engineering, you need a separate mechanism for each component.” 

Ultimately, the study found that the addition of sialidase improved the efficiency of the therapy against cancer. The next step for the sialidase enzyme therapy would be testing it in animals before it could advance to human trials. The study was supported by Wellcome with funding from the National Institute of Health,  UKRI,  Leverhulme Trust, and the EU’s Horizon 2020 programme. This study showed the untapped potential that using click chemistry to develop future therapies has.

©www.geneonline.com All rights reserved. Collaborate with us: [email protected]
Related Post
Ipsen Bets $600M on Biomunex’s First-in-Class T-Cell Engager BMX-502
2024-12-03
GeneOnline’s Weekly News Highlights: July 24-28
2023-08-01
HIV Latent Cells Could Lead to Possible Cure
2022-07-28
LATEST
Beyond Pouch Packaging: Hanmi Pharmaceutical Introduces a New Automated Vial Dispensing Solution in Canada and the United States
2025-02-13
NASA Says There’s a 1 in 43 Chance an Asteroid 2024 YR4 Could Hit Earth in 2032—Should We Worry?
2025-02-13
Sodium Channel Targeting: What the Latest FDA Non-Opioid Approval Reveals About the Next Big Thing in Pain Relief
2025-02-12
Novartis Reclaims Abelacimab in $925M Deal to Boost Cardiovascular Portfolio
2025-02-12
GLP-1 Weight Loss Drugs Might Cause Blindness
2025-02-11
South Korea’s Olix Strikes $660M Deal with Eli Lilly for Phase 1 MASH candidate
2025-02-11
22 USA States Sue Trump Administration for Slashing Critical Medical Research Funding
2025-02-11
EVENT
2025-02-19
Healthcare Conference Taipei 2025
Taipei, Taiwan
2025-03-04
MIXiii Health-Tech.IL
Jerusalem, Israel
2025-03-05
Medical Japan
Osaka, Japan
2025-03-17
BIO-Europe Spring 2025
Milan, Italy
2025-04-21
World Vaccine Congress 2025
Washington, U.S.A
Scroll to Top