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November 23, 2015: Stanford Scientists Proved the Importance of lincRNAs in Human Embryo Development
November 23, 2015, researchers from Stanford University published a study on Nature Genetics demonstrating the importance of primate-specific noncoding RNA, human pluripotency-associated transcripts 2, 3 and 5 (HPAT2, HPAT3 and HPAT5), during human preimplantation development and nuclear reprogramming. Large primate-specific long intergenic noncoding RNA (lincRNA) families modulate gene expression during development and differentiation to reinforce cell fate. CRISPR-mediated disruption of the genes for these lincRNAs in pluripotent stem cells, followed by whole-transcriptome analysis, identifies HPAT5 as a key component of the pluripotency network.
Reference
https://www.ncbi.nlm.nih.gov/pubmed/26595768
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