GENE ONLINE|News &
Opinion
Blog

2023-12-25| Asia-Pacific

AstraZeneca’s severe asthma drug Tezspire has been granted market authorization in South Korea

by Oscar Wu
Share To

The Ministry of Food and Drug Safety (MFDS) in South Korea approved Tezspire on Thursday, granting AstraZeneca Korea market authorization for the drug. Tezspire was previously approved by the United States Food and Drug Administration (FDA) on December 17, 2021, for the treatment of severe asthma.

Tezspire is a novel treatment for severe asthma in adults and adolescents over 12 years old. The approved indications for Tezspire are for patients aged 12 and older who have severe asthma that is not adequately controlled with standard maintenance treatments, such as high-dose inhaled corticosteroids and other asthma medications.

New TSLP Blocker for Asthma Control

Tezspire is a thymic stromal lymphopoietin (TSLP) blocker, a human monoclonal antibody IgG2λ, which can bind to TSLP and effectively reduce TSLP-induced inflammatory responses. This mechanism not only significantly reduces the frequency of asthma attacks but also improves patient breathing and lung function, enhancing control over asthma symptoms.

Asthma Mainly Arises from Inflammation and Hypersensitivity of the Airways

The common cause of asthma is the stimulation of the epithelial cell layer by various external irritants, such as viruses, allergens, pollutants/smoke, bacteria, and other external stimuli, which promote the release of TSLP and induce inflammation.

Clinically, asthma has 2 main characteristics: airway inflammation or hyperresponsiveness. Airway inflammation is related to various cytokines and different types of immune responses, mainly divided into 3 situations: firstly, allergic inflammation caused by IL-4 accompanied by increased levels of IgE. Secondly, allergic and eosinophilic inflammation caused by IL-4, IL-5, and IL-13, characterized by elevated levels of IgE, fractional exhaled nitric oxide (FeNO), and eosinophils. Finally, eosinophilic inflammation is caused solely by IL-5, mainly characterized by the accumulation of eosinophils.

Another key feature of asthma: airway hypersensitivity, highlights the role of mast cells in the immune system, which can initiate and enhance inflammatory responses by releasing histamine and other mediators.

Finally, it is worth noting that Tezspire does not specify a particular phenotype (such as eosinophilic or allergic) or biomarker restrictions in its approved label, making it flexible and offering a more comprehensive treatment option for patients with severe asthma.

©www.geneonline.com All rights reserved. Collaborate with us: service@geneonlineasia.com
Author
Related Post
AstraZeneca’s $1.5 Billion ADC Manufacturing Facility in Singapore
2024-05-23
Asthma Medications: From Quick Relief to Long-Term Control
2024-03-11
Pharmaceutical Giants Expand Research and Manufacturing Capabilities, Fueling 2024 Innovation and Growth
2024-03-01
LATEST
Company Presentations at BIO 2024 Inspire Partnering
2024-06-14
GV Regains Compliance with Nasdaq Minimum Bid Price Requirement
2024-06-13
ARPA-H Fast-Tracks Biotech Startups: Funding Insights from BIO 2024 Panel
2024-06-12
Gene Therapy Innovations and Financial Challenges for the Future of Medicine
2024-06-12
BIO Releases DEI Survey in Partnership with Korn Ferry
2024-06-11
Advancing Healthcare Accessibility and Sustainable Development
2024-06-11
New CRISPR Method Enables Gene Edits in Cockroaches and All Insects
2024-06-11
EVENT
Scroll to Top